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Dual mechanism ?-amino acid polymers promoting cell adhesion.

ABSTRACT: Cell adhesion has tremendous impact on the function of culture platforms and implants. Cell-adhesive proteins and peptides have been extensively used for decades to promote cell adhesion, however, their application suffers from their easy enzymatic degradation, difficulty in large-scale preparation and expensiveness. To develop the next-generation cell-adhesive materials, we mimic the cell adhesion functions and mechanisms of RGD and KRSR peptides and design cell-adhesive cationic-hydrophobic amphiphilic ?-amino acid polymers that are stable upon proteolysis and easily prepared in large scale at low cost. The optimal polymer strongly promotes cell adhesion, using preosteoblast cell as a model, by following dual mechanisms that are independent of sequence and chirality of the statistic copolymer. Our strategy opens avenues in designing the next-generation cell-adhesive materials and may guide future studies and applications.

SUBMITTER: Chen Q

PROVIDER: S-EPMC7835237 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Dual mechanism β-amino acid polymers promoting cell adhesion.

Chen Qi Q Zhang Donghui D Zhang Wenjing W Zhang Haodong H Zou Jingcheng J Chen Mingjiao M Li Jin J Yuan Yuan Y Liu Runhui R

Nature communications 20210125 1

Cell adhesion has tremendous impact on the function of culture platforms and implants. Cell-adhesive proteins and peptides have been extensively used for decades to promote cell adhesion, however, their application suffers from their easy enzymatic degradation, difficulty in large-scale preparation and expensiveness. To develop the next-generation cell-adhesive materials, we mimic the cell adhesion functions and mechanisms of RGD and KRSR peptides and design cell-adhesive cationic-hydrophobic am ...[more]

PMID: 33495467

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