Ontology highlight
ABSTRACT:
SUBMITTER: Ashworth S
PROVIDER: S-EPMC7835413 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Ashworth Sean S Harrington Jodie J Hammond Greg M GM Bains Kiranjit K KK Koudouna Elena E Hayes Anthony J AJ Ralphs James R JR Regini Justyn W JW Young Robert D RD Hayashi Ryuhei R Nishida Kohji K Hughes Clare E CE Quantock Andrew J AJ
Frontiers in cell and developmental biology 20210112
Chondroitin sulfate (CS) is an important component of the extracellular matrix in multiple biological tissues. In cornea, the CS glycosaminoglycan (GAG) exists in hybrid form, whereby some of the repeating disaccharides are dermatan sulfate (DS). These CS/DS GAGs in cornea, through their presence on the proteoglycans, decorin and biglycan, help control collagen fibrillogenesis and organization. CS also acts as a regulatory ligand for a spectrum of signaling molecules, including morphogens, cytok ...[more]