Ontology highlight
ABSTRACT:
SUBMITTER: Chowdhury SR
PROVIDER: S-EPMC7835851 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Chowdhury Subir Roy SR Peltier Cheryl C Hou Sen S Singh Amandeep A Johnston James B JB Gibson Spencer B SB Marshall Aaron A Banerji Versha V
Cancers 20210119 2
Mitochondrial respiration is becoming more commonly used as a preclinical tool and potential biomarker for chronic lymphocytic leukemia (CLL) and activated B-cell receptor (BCR) signaling. However, respiration parameters have not been evaluated with respect to dose of ibrutinib given in clinical practice or the effect of progression on ibrutinib treatment on respiration of CLL cells. We evaluated the impact of low and standard dose ibrutinib on CLL cells from patients treated in vivo on mitochon ...[more]