Ontology highlight
ABSTRACT:
SUBMITTER: Gelardi ELM
PROVIDER: S-EPMC7835878 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Gelardi Edoardo L M ELM Colombo Giorgia G Picarazzi Francesca F Ferraris Davide M DM Mangione Andrea A Petrarolo Giovanni G Aronica Eleonora E Rizzi Menico M Mori Mattia M La Motta Concettina C Garavaglia Silvia S
Cancers 20210119 2
Aldehyde dehydrogenase 1A3 (ALDH1A3) belongs to an enzymatic superfamily composed by 19 different isoforms, with a scavenger role, involved in the oxidation of a plethora of aldehydes to the respective carboxylic acids, through a NAD+-dependent reaction. Previous clinical studies highlighted the high expression of ALDH1A3 in cancer stem cells (CSCs) correlated to a higher risk of cancer relapses, chemoresistance and a poor clinical outcome. We report on the structural, biochemical, and cellular ...[more]