Nanomaterial Delivery Systems for mRNA Vaccines.
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ABSTRACT:
SUBMITTER: Buschmann MD
PROVIDER: S-EPMC7836001 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
Nanomaterial Delivery Systems for mRNA Vaccines.
Buschmann Michael D MD Carrasco Manuel J MJ Alishetty Suman S Paige Mikell M Alameh Mohamad Gabriel MG Weissman Drew D
Vaccines 20210119 1
The recent success of mRNA vaccines in SARS-CoV-2 clinical trials is in part due to the development of lipid nanoparticle delivery systems that not only efficiently express the mRNA-encoded immunogen after intramuscular injection, but also play roles as adjuvants and in vaccine reactogenicity. We present an overview of mRNA delivery systems and then focus on the lipid nanoparticles used in the current SARS-CoV-2 vaccine clinical trials. The review concludes with an analysis of the determinants o ...[more]
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