Ontology highlight
ABSTRACT:
SUBMITTER: Trevino JT
PROVIDER: S-EPMC7836101 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Trevino J T JT Quispe R C RC Khan F F Novak V V
Journal of clinical trials 20201210 7
Intranasal drug administration is a promising method for delivering drugs directly to the brain. Animal studies have described pathways and potential brain targets, but nose-to-brain delivery and treatment efficacy in humans remains debated. We describe the proposed pathways and barriers for nose-to-brain drug delivery in humans, drug properties that influence central nervous system delivery, clinically tested methods to enhance absorption, and the devices used in clinical trials. This review co ...[more]