A network pharmacology perspective for deciphering potential mechanisms of action of Solanum nigrum L. in bladder cancer.

ABSTRACT:

Background

Solanum nigrum L. decoction has been used as a folklore medicine in China to prevent the postoperative recurrence of bladder cancer (BC). However, there are no previous pharmacological studies on the protective mechanisms of this activity of the plant. Thus, this study aimed to perform a systematic analysis and to predict the potential action mechanisms underlying S. nigrum activity in BC based on network pharmacology.

Methods

Based on network pharmacology, the active ingredients of S. nigrum and the corresponding targets were identified using the Traditional Chinese Medicines for Systems Pharmacology Database and Analysis Platform database, and BC-related genes were screened using GeneCards and the Online Mendelian Inheritance in Man database. In addition, ingred

SUBMITTER: Dong Y 

PROVIDER: S-EPMC7836472 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature