Ontology highlight
ABSTRACT:
SUBMITTER: Kuijpers M
PROVIDER: S-EPMC7837115 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Kuijpers Marijn M Kochlamazashvili Gaga G Stumpf Alexander A Puchkov Dmytro D Swaminathan Aarti A Lucht Max Thomas MT Krause Eberhard E Maritzen Tanja T Schmitz Dietmar D Haucke Volker V
Neuron 20201105 2
Neurons are known to rely on autophagy for removal of defective proteins or organelles to maintain synaptic neurotransmission and counteract neurodegeneration. In spite of its importance for neuronal health, the physiological substrates of neuronal autophagy in the absence of proteotoxic challenge have remained largely elusive. We use knockout mice conditionally lacking the essential autophagy protein ATG5 and quantitative proteomics to demonstrate that loss of neuronal autophagy causes selectiv ...[more]