Ontology highlight
ABSTRACT:
SUBMITTER: Wolanski M
PROVIDER: S-EPMC7837296 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Wolański Marcin M Krawiec Michał M Schwarz Paul N PN Stegmann Evi E Wohlleben Wolfgang W Buchmann Anina A Gross Harald H Eitel Michael M Koch Pierre P Botas Alma A Méndez Carmen C Núñez Luz Elena LE Morís Francisco F Cortés Jesus J Zakrzewska-Czerwińska Jolanta J
Engineering in life sciences 20201104 1-2
Brasilicardin A (BraA) is a promising immunosuppressive compound produced naturally by the pathogenic bacterium <i>Nocardia terpenica</i> IFM 0406. Heterologous host expression of brasilicardin gene cluster showed to be efficient to bypass the safety issues, low production levels and lack of genetic tools related with the use of native producer. Further improvement of production yields requires better understanding of gene expression regulation within the BraA biosynthetic gene cluster (Bra-BGC) ...[more]