Ontology highlight
ABSTRACT:
SUBMITTER: Song Z
PROVIDER: S-EPMC7838030 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Song Zhendong Z Wang Meijing M Ge Yang Y Chen Xue-Ping XP Xu Ziyang Z Sun Yang Y Xiong Xiao-Feng XF
Acta pharmaceutica Sinica. B 20200726 1
Src homology containing protein tyrosine phosphatase 2 (SHP2) represents a noteworthy target for various diseases, serving as a well-known oncogenic phosphatase in cancers. As a result of the low cell permeability and poor bioavailability, the traditional inhibitors targeting the protein tyrosine phosphate catalytic sites are generally suffered from unsatisfactory applied efficacy. Recently, a particularly large number of allosteric inhibitors with striking inhibitory potency on SHP2 have been i ...[more]