Ontology highlight
ABSTRACT:
SUBMITTER: Noji M
PROVIDER: S-EPMC7838177 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Noji Masahiro M Samejima Tatsushi T Yamaguchi Keiichi K So Masatomo M Yuzu Keisuke K Chatani Eri E Akazawa-Ogawa Yoko Y Hagihara Yoshihisa Y Kawata Yasushi Y Ikenaka Kensuke K Mochizuki Hideki H Kardos József J Otzen Daniel E DE Bellotti Vittorio V Buchner Johannes J Goto Yuji Y
Communications biology 20210126 1
The thermodynamic hypothesis of protein folding, known as the "Anfinsen's dogma" states that the native structure of a protein represents a free energy minimum determined by the amino acid sequence. However, inconsistent with the Anfinsen's dogma, globular proteins can misfold to form amyloid fibrils, which are ordered aggregates associated with diseases such as Alzheimer's and Parkinson's diseases. Here, we present a general concept for the link between folding and misfolding. We tested the acc ...[more]