Ontology highlight
ABSTRACT:
SUBMITTER: Li L
PROVIDER: S-EPMC7838256 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Li Lei L Wei Jia-Ru JR Song Ye Y Fang Shuo S Du Yanyu Y Li Zhuo Z Zeng Ting-Ting TT Zhu Ying-Hui YH Li Yan Y Guan Xin-Yuan XY
Cell death & disease 20210126 1
Hepatocellular carcinoma (HCC) is one of the common malignancy and lacks effective therapeutic targets. Here, we demonstrated that ectopic expression of trophinin-associated protein (TROAP) dramatically drove HCC cell growth assessed by foci formation in monolayer culture, colony formation in soft agar and orthotopic liver transplantation in nude mice. Inversely, silencing TROAP expression with short-hairpin RNA attenuated the malignant proliferation of HCC cells in vitro and in vivo. Next, mech ...[more]