Ontology highlight
ABSTRACT:
SUBMITTER: Shorrocks AK
PROVIDER: S-EPMC7838300 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Shorrocks Ann-Marie K AK Jones Samuel E SE Tsukada Kaima K Morrow Carl A CA Belblidia Zoulikha Z Shen Johanna J Vendrell Iolanda I Fischer Roman R Kessler Benedikt M BM Blackford Andrew N AN
Nature communications 20210126 1
The Bloom syndrome helicase BLM interacts with topoisomerase IIIα (TOP3A), RMI1 and RMI2 to form the BTR complex, which dissolves double Holliday junctions to produce non-crossover homologous recombination (HR) products. BLM also promotes DNA-end resection, restart of stalled replication forks, and processing of ultra-fine DNA bridges in mitosis. How these activities of the BTR complex are regulated in cells is still unclear. Here, we identify multiple conserved motifs within the BTR complex tha ...[more]