Ontology highlight
ABSTRACT:
SUBMITTER: Li S
PROVIDER: S-EPMC7838669 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Li Sheng S Cui Zhengli Z Meng Xianfeng X
Oncology research 20160101 4
Poly(ADP-ribose) polymerase 1 (PARP-1) is reported to be involved in DNA repair and is now recognized as a key regulator in carcinogenesis. However, the potential role and the molecular mechanism underlying the effect of PARP-1 on osteosarcoma (OS) cells have not been elucidated. In this study, the results showed that knockdown of PARP-1 resulted in decreased cell proliferation, increased cell apoptosis, and G0/G1 phase arrest in U2OS cells. In addition, increased expression of active caspase 3 ...[more]