Ontology highlight
ABSTRACT:
SUBMITTER: Lou Y
PROVIDER: S-EPMC7838722 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Lou Ye Y Liu Lei L Zhan Lihui L Wang Xuewei X Fan Hua H
Oncology research 20160101 2
Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy and causes a high rate of mortality in affected adults. Many subtypes of ALL exist with disruptions in distinct genetic pathways, including those regulated by miRNAs. Here we identify miR-187-5p as being highly upregulated in B-cell ALL and a driver of cellular proliferation and suppressor of apoptosis. We show that miR-187-5p directly targets the 3'-UTR of DKK2 to mediate these effects. We further determine that inhibiti ...[more]