Ontology highlight
ABSTRACT:
SUBMITTER: Dugourd A
PROVIDER: S-EPMC7838823 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Dugourd Aurelien A Kuppe Christoph C Sciacovelli Marco M Gjerga Enio E Gabor Attila A Emdal Kristina B KB Vieira Vitor V Bekker-Jensen Dorte B DB Kranz Jennifer J Bindels Eric M J EMJ Costa Ana S H ASH Sousa Abel A Beltrao Pedro P Rocha Miguel M Olsen Jesper V JV Frezza Christian C Kramann Rafael R Saez-Rodriguez Julio J
Molecular systems biology 20210101 1
Multi-omics datasets can provide molecular insights beyond the sum of individual omics. Various tools have been recently developed to integrate such datasets, but there are limited strategies to systematically extract mechanistic hypotheses from them. Here, we present COSMOS (Causal Oriented Search of Multi-Omics Space), a method that integrates phosphoproteomics, transcriptomics, and metabolomics datasets. COSMOS combines extensive prior knowledge of signaling, metabolic, and gene regulatory ne ...[more]