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Portal Dissemination of Fusarium graminearum in a Patient with Acute Lymphoblastic Leukemia and Febrile Neutropenia.


ABSTRACT: We present the case of a man with acute lymphoblastic leukemia and prolonged profound neutropenia, who developed an invasive infection by Fusarium graminearum, acquired via non-cutaneous entry, with gastrointestinal symptoms, sigmoid perforation and liver abscesses due to portal dissemination. The etiologic agent was identified using the 18S-ITS1-5.8S-ITS2-28S rRNA sequence gene, from a liver biopsy. The infection was resolved with surgical drainage and antifungal treatment based on voriconazole. As far as we know, there are no previous reports in the literature of cases of human infection due to Fusarium graminearum.

SUBMITTER: Uscamayta MG 

PROVIDER: S-EPMC7838889 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Portal Dissemination of <i>Fusarium graminearum</i> in a Patient with Acute Lymphoblastic Leukemia and Febrile Neutropenia.

Uscamayta Mary Gabriela MG   Martin-Onraet Alexandra A   Espinosa-Bautista Karla K   Herrera-Goepfert Roberto R   Hernández-Castro Rigoberto R   Perez-Jimenez Carolina C  

Infectious disease reports 20210101 1


We present the case of a man with acute lymphoblastic leukemia and prolonged profound neutropenia, who developed an invasive infection by <i>Fusarium graminearum</i>, acquired via non-cutaneous entry, with gastrointestinal symptoms, sigmoid perforation and liver abscesses due to portal dissemination. The etiologic agent was identified using the 18S-ITS1-5.8S-ITS2-28S rRNA sequence gene, from a liver biopsy. The infection was resolved with surgical drainage and antifungal treatment based on voric  ...[more]

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