Dataset Information

The presence of Aspergillus fumigatus is associated with worse respiratory quality of life in cystic fibrosis.

ABSTRACT:

Background

The clinical effects of Aspergillus fumigatus in the cystic fibrosis (CF) airway, with the exception of allergic bronchopulmonary aspergillosis, is unclear.

Methods

CF adolescents and adults (age 14?years and older) underwent bacterial and semi-selective fungal culture testing to determine the prevalence of fungi in the CF respiratory tract and the independent association between the presence of Aspergillus fumigatus and clinical characteristics.

Results

Aspergillus fumigatus (10.3%) and Candida species (57.8%) were the most common filamentous fungi and yeast seen respectively in the sputa of 206 individuals with CF. Inhaled corticosteroid (ICS) use was more common in Aspergillus fumigatus-positive than Aspergillus fumigatusnegative (100% versus 75.8%, p?=?.01). Aspergillus fumigatus was significantly associated with lower respiratory domain score (? -8.74, 95% CI -16.6, -0.88, p?=?.03), representing worse respiratory-related quality of life, accounting for demographics, disease characteristics, and the presence of a pulmonary exacerbation.

Conclusion

The presence of Aspergillus fumigatus in CF sputum was associated with worse respiratory quality of life in CF in a crosssectional, single center study. Longitudinal analysis examining the clinical implications of Aspergillus fumigatus on respiratory health over time is needed.

SUBMITTER: Hong G

PROVIDER: S-EPMC7839066 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Publications

The presence of Aspergillus fumigatus is associated with worse respiratory quality of life in cystic fibrosis.

Hong Gina G Alby Kevin K Ng Sharon C W SCW Fleck Victoria V Kubrak Christina C Rubenstein Ronald C RC Dorgan Daniel J DJ Kawut Steven M SM Hadjiliadis Denis D

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 20190821 1

<h4>Background</h4>The clinical effects of Aspergillus fumigatus in the cystic fibrosis (CF) airway, with the exception of allergic bronchopulmonary aspergillosis, is unclear.<h4>Methods</h4>CF adolescents and adults (age 14 years and older) underwent bacterial and semi-selective fungal culture testing to determine the prevalence of fungi in the CF respiratory tract and the independent association between the presence of Aspergillus fumigatus and clinical characteristics.<h4>Results</h4>Aspergil ...[more]

PMID: 31446018

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Project description:Health-related and disease-specific quality of life (HRQoL) has been increasingly valued as relevant clinical parameter in cystic fibrosis (CF) clinical care and clinical trials. HRQoL measures should assess - among other domains - daily functioning from a patient's perspective. However, validation studies for the most frequently used HRQoL questionnaire in CF, the Cystic Fibrosis Questionnaire (CFQ), have not included measures of physical activity or fitness. The objective of this study was, therefore, to determine the cross-sectional and longitudinal relationships between HRQoL, physical activity and fitness in patients with CF.Baseline (n = 76) and 6-month follow-up data (n = 70) from patients with CF (age ?12 years, FEV1 ?35%) were analysed. Patients participated in two multi-centre exercise intervention studies with identical assessment methodology. Outcome variables included HRQoL (German revised multi-dimensional disease-specific CFQ (CFQ-R)), body composition, pulmonary function, physical activity, short-term muscle power, and aerobic fitness by peak oxygen uptake and aerobic power.Peak oxygen uptake was positively related to 7 of 13 HRQoL scales cross-sectionally (r = 0.30-0.46). Muscle power (r = 0.25-0.32) and peak aerobic power (r = 0.24-0.35) were positively related to 4 scales each, and reported physical activity to 1 scale (r = 0.29). Changes in HRQoL-scores were directly and significantly related to changes in reported activity (r = 0.35-0.39), peak aerobic power (r = 0.31-0.34), and peak oxygen uptake (r = 0.26-0.37) in 3 scales each. Established associates of HRQoL such as FEV1 or body mass index correlated positively with fewer scales (all 0.24 < r < 0.55).HRQoL was associated with physical fitness, especially aerobic fitness, and to a lesser extent with reported physical activity. These findings underline the importance of physical fitness for HRQoL in CF and provide an additional rationale for exercise testing in this population.ClinicalTrials.gov, NCT00231686.

Dataset Information

The presence of Aspergillus fumigatus is associated with worse respiratory quality of life in cystic fibrosis.

Background

Methods

Results

Conclusion

Publications

The presence of Aspergillus fumigatus is associated with worse respiratory quality of life in cystic fibrosis.

Similar Datasets

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