Ontology highlight
ABSTRACT:
SUBMITTER: Tang T
PROVIDER: S-EPMC7839419 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Tang Tiffany T Jaimes Javier A JA Bidon Miya K MK Straus Marco R MR Daniel Susan S Whittaker Gary R GR
ACS infectious diseases 20210112 2
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses its spike (S) protein to mediate viral entry into host cells. Cleavage of the S protein at the S1/S2 and/or S2' site(s) is associated with viral entry, which can occur at either the cell plasma membrane (early pathway) or the endosomal membrane (late pathway), depending on the cell type. Previous studies show that SARS-CoV-2 has a unique insert at the S1/S2 site that can be cleaved by furin, which appears to expand viral tropi ...[more]