Ontology highlight
ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC7839515 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Wang Jinhua J Wicher Barbara B Maurizot Victor V Huc Ivan I
Chemistry (Weinheim an der Bergstrasse, Germany) 20201203 3
Quinoline based aromatic amide foldamers are known to adopt stable folded conformations. We have developed a synthetic approach to produce similar oligomers where all amide bonds, or part of them, have been replaced by an isosteric vinylene group. The results of solution and solid state structural studies show that oligomers exclusively containing vinylene linkages are not well folded, and adopt predominantly flat conformations. In contrast, a vinylene segment flanked by helical oligoamides also ...[more]