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ABSTRACT:
SUBMITTER: Scherubl M
PROVIDER: S-EPMC7839731 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Scherübl Maximilian M Daniliuc Constantin G CG Studer Armido A
Angewandte Chemie (International ed. in English) 20201210 2
The application of arynes as radical acceptors is described. The stable radical TEMPO (2,2,6,6-tetramethyl piperidine 1-oxyl) is shown to add to various ortho-substituted benzynes generating the corresponding aryl radicals which engage in 5-exo or 6-endo cyclizations. The cyclized radicals are eventually trapped by TEMPO. The introduced method provides ready access to various dihydrobenzofurans, oxindoles, and sultones by a conceptually novel approach. ...[more]