Unknown

Dataset Information

0

Empagliflozin treatment effects across categories of baseline HbA1c, body weight and blood pressure as an add-on to metformin in patients with type 2 diabetes.


ABSTRACT:

Aim

To investigate the association of different categories of baseline cardio-metabolic risk factors on the treatment effects of empagliflozin 10 and 25?mg when added as second-line therapy to metformin in patients with type 2 diabetes (T2D).

Materials and methods

Patients aged 18?years or older with HbA1c 7.0%-10.0% were included. Analysis of covariance compared change from baseline to weeks 24 and 76 in HbA1c, body weight (BW) and systolic blood pressure (SBP) by respective baseline categories (HbA1c <8.5/?8.5%; BW <80/80-90/>90?kg, SBP <130/130-140/>140?mmHg). Analyses were also conducted with a model using continuous covariates of cardio-metabolic factors.

Results

In total, 637 patients (56.7% males; mean [SD] age 55.7 [9.9] years, HbA1c 7.9% [0.9%], BW 81.2 [18.8] kg, SBP 129.4 [14.6] mmHg) received one or more dose of either empagliflozin 10 mg (n = 217) or 25?mg (n = 213), or placebo (n = 207). At both time points, empagliflozin 10/25?mg versus placebo significantly (P?< .0001) reduced HbA1c and BW, with greater reductions in HbA1c at higher baseline HbA1c (P interaction week 24/76 categorical and continuous models: .0290/.1431 and .0004/.0042, respectively) and in BW (P interaction .1340/.0012 and .0202/<.0001, respectively). Both empagliflozin doses also significantly lowered SBP versus placebo at both time points, with similar efficacy by subgroups of baseline SBP. Adverse events were consistent with the established empagliflozin safety profile across treatment groups.

Conclusions

Empagliflozin, as add-on to metformin, decreases HbA1c and BW, particularly in patients with higher HbA1c and BW baseline values, and effectively lowers SBP.

SUBMITTER: Inzucchi SE 

PROVIDER: S-EPMC7839733 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

altmetric image

Publications

Empagliflozin treatment effects across categories of baseline HbA1c, body weight and blood pressure as an add-on to metformin in patients with type 2 diabetes.

Inzucchi Silvio E SE   Davies Melanie J MJ   Khunti Kamlesh K   Trivedi Prabhav P   George Jyothis T JT   Zwiener Isabella I   Johansen Odd Erik OE   Sattar Naveed N  

Diabetes, obesity & metabolism 20201120 2


<h4>Aim</h4>To investigate the association of different categories of baseline cardio-metabolic risk factors on the treatment effects of empagliflozin 10 and 25 mg when added as second-line therapy to metformin in patients with type 2 diabetes (T2D).<h4>Materials and methods</h4>Patients aged 18 years or older with HbA1c 7.0%-10.0% were included. Analysis of covariance compared change from baseline to weeks 24 and 76 in HbA1c, body weight (BW) and systolic blood pressure (SBP) by respective base  ...[more]

Similar Datasets

| S-EPMC5111757 | biostudies-literature
| S-EPMC4800739 | biostudies-literature
| S-EPMC4900973 | biostudies-literature
| S-EPMC5638095 | biostudies-literature
| S-EPMC6354821 | biostudies-other
| S-EPMC7669324 | biostudies-literature
| S-EPMC5715655 | biostudies-literature
| S-EPMC5576872 | biostudies-literature
| S-EPMC8323908 | biostudies-literature
| S-EPMC5783643 | biostudies-literature