Ontology highlight
ABSTRACT:
SUBMITTER: He H
PROVIDER: S-EPMC7839975 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
He Hongjian H Lin Xinyi X Wu Difei D Wang Jiaqing J Guo Jiaqi J Green Douglas R DR Zhang Hongwei H Xu Bing B
Cell reports. Physical science 20201209 12
Since mitochondria contribute to tumorigenesis and drug resistance in cancer, mitochondrial genetic engineering promises a new direction for cancer therapy. Here, we report the use of the perimitochondrial enzymatic noncovalent synthesis (ENS) of peptides for delivering genes selectively into the mitochondria of cancer cells for mitochondrial genetic engineering. Specifically, the micelles of peptides bind to the voltage-dependent anion channel (VDAC) on mitochondria for the proteolysis by enter ...[more]