Ontology highlight
ABSTRACT:
SUBMITTER: Mwangangi DM
PROVIDER: S-EPMC7840138 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Science advances 20210127 5
Uncapping of actin filaments is essential for driving polymerization and depolymerization dynamics from capping protein-associated filaments; however, the mechanisms of uncapping leading to rapid disassembly are unknown. Here, we elucidated the x-ray crystal structure of the actin/twinfilin/capping protein complex to address the mechanisms of twinfilin uncapping of actin filaments. The twinfilin/capping protein complex binds to two G-actin subunits in an orientation that resembles the actin fila ...[more]