Ontology highlight
ABSTRACT:
SUBMITTER: Hussaini S
PROVIDER: S-EPMC7840178 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Hussaini Sayedeh S Venkatesan Vishalini V Biasci Valentina V Romero Sepúlveda José M JM Quiñonez Uribe Raul A RA Sacconi Leonardo L Bub Gil G Richter Claudia C Krinski Valentin V Parlitz Ulrich U Majumder Rupamanjari R Luther Stefan S
eLife 20210127
The development of new approaches to control cardiac arrhythmias requires a deep understanding of spiral wave dynamics. Optogenetics offers new possibilities for this. Preliminary experiments show that sub-threshold illumination affects electrical wave propagation in the mouse heart. However, a systematic exploration of these effects is technically challenging. Here, we use state-of-the-art computer models to study the dynamic control of spiral waves in a two-dimensional model of the adult mouse ...[more]