Unknown

Dataset Information

0

Drift and termination of spiral waves in optogenetically modified cardiac tissue at sub-threshold illumination.


ABSTRACT: The development of new approaches to control cardiac arrhythmias requires a deep understanding of spiral wave dynamics. Optogenetics offers new possibilities for this. Preliminary experiments show that sub-threshold illumination affects electrical wave propagation in the mouse heart. However, a systematic exploration of these effects is technically challenging. Here, we use state-of-the-art computer models to study the dynamic control of spiral waves in a two-dimensional model of the adult mouse ventricle, using stationary and non-stationary patterns of sub-threshold illumination. Our results indicate a light-intensity-dependent increase in cellular resting membrane potentials, which together with diffusive cell-cell coupling leads to the development of spatial voltage gradients over differently illuminated areas. A spiral wave drifts along the positive gradient. These gradients can be strategically applied to ensure drift-induced termination of a spiral wave, both in optogenetics and in conventional methods of electrical defibrillation.

SUBMITTER: Hussaini S 

PROVIDER: S-EPMC7840178 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications


The development of new approaches to control cardiac arrhythmias requires a deep understanding of spiral wave dynamics. Optogenetics offers new possibilities for this. Preliminary experiments show that sub-threshold illumination affects electrical wave propagation in the mouse heart. However, a systematic exploration of these effects is technically challenging. Here, we use state-of-the-art computer models to study the dynamic control of spiral waves in a two-dimensional model of the adult mouse  ...[more]

Similar Datasets

| S-EPMC555701 | biostudies-literature
| S-EPMC3019092 | biostudies-literature
| S-EPMC4637448 | biostudies-literature
| S-EPMC10196067 | biostudies-literature
| S-EPMC1913880 | biostudies-other
| S-EPMC6713330 | biostudies-literature
| S-EPMC7691998 | biostudies-literature
| S-EPMC2789171 | biostudies-literature
| S-EPMC1177368 | biostudies-literature
| S-EPMC4003477 | biostudies-other