Ontology highlight
ABSTRACT:
SUBMITTER: Franzosa JA
PROVIDER: S-EPMC7840683 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Franzosa Jill A JA Bonzo Jessica A JA Jack John J Baker Nancy C NC Kothiya Parth P Witek Rafal P RP Hurban Patrick P Siferd Stephen S Hester Susan S Shah Imran I Ferguson Stephen S SS Houck Keith A KA Wambaugh John F JF
NPJ systems biology and applications 20210127 1
The ToxCast in vitro screening program has provided concentration-response bioactivity data across more than a thousand assay endpoints for thousands of chemicals found in our environment and commerce. However, most ToxCast screening assays have evaluated individual biological targets in cancer cell lines lacking integrated physiological functionality (such as receptor signaling, metabolism). We evaluated differentiated HepaRG<sup>TM</sup> cells, a human liver-derived cell model understood to ef ...[more]