Ontology highlight
ABSTRACT:
SUBMITTER: Bai Y
PROVIDER: S-EPMC7840714 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Bai Ying Y Wang Xuye X Cai Mengsi M Ma Chunbo C Xiang Youqun Y Hu Wanle W Zhou Bin B Zhao Chengguang C Dai Xuanxuan X Li Xiaokun X Zhao Haiyang H
American journal of cancer research 20210101 1
Colorectal cancer (CRC) has become one of the most common types of cancer with the highest morbidity and mortality rates globally. Cinobufagin, a natural product extracted from toad venom and a major active ingredient in cinobufotalin, exhibits high antitumor activity. Here, we investigated the <i>in vitro</i> and <i>in vivo</i> antitumor activities of cinobufagin and explored the underlying mechanisms in CRC. Cinobufagin could inhibit proliferation, migration, invasion and promote apoptosis of ...[more]