Distinct epigenetic signatures between adult-onset and late-onset depression.
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ABSTRACT:
SUBMITTER: Yamagata H
PROVIDER: S-EPMC7840753 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
Distinct epigenetic signatures between adult-onset and late-onset depression.
Yamagata Hirotaka H Ogihara Hiroyuki H Matsuo Koji K Uchida Shusaku S Kobayashi Ayumi A Seki Tomoe T Kobayashi Masaaki M Harada Kenichiro K Chen Chong C Miyata Shigeo S Fukuda Masato M Mikuni Masahiko M Hamamoto Yoshihiko Y Watanabe Yoshifumi Y Nakagawa Shin S
Scientific reports 20210127 1
The heterogeneity of major depressive disorder (MDD) is attributed to the fact that diagnostic criteria (e.g., DSM-5) are only based on clinical symptoms. The discovery of blood biomarkers has the potential to change the diagnosis of MDD. The purpose of this study was to identify blood biomarkers of DNA methylation by strategically subtyping patients with MDD by onset age. We analyzed genome-wide DNA methylation of patients with adult-onset depression (AOD; age ≥ 50 years, age at depression onse ...[more]
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