Ontology highlight
ABSTRACT:
SUBMITTER: Renders S
PROVIDER: S-EPMC7840807 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Renders Simon S Svendsen Arthur Flohr AF Panten Jasper J Rama Nicolas N Maryanovich Maria M Sommerkamp Pia P Ladel Luisa L Redavid Anna Rita AR Gibert Benjamin B Lazare Seka S Ducarouge Benjamin B Schönberger Katharina K Narr Andreas A Tourbez Manon M Dethmers-Ausema Bertien B Zwart Erik E Hotz-Wagenblatt Agnes A Zhang Dachuan D Korn Claudia C Zeisberger Petra P Przybylla Adriana A Sohn Markus M Mendez-Ferrer Simon S Heikenwälder Mathias M Brune Maik M Klimmeck Daniel D Bystrykh Leonid L Frenette Paul S PS Mehlen Patrick P de Haan Gerald G Cabezas-Wallscheid Nina N Trumpp Andreas A
Nature communications 20210127 1
Haematopoietic stem cells (HSCs) are characterized by their self-renewal potential associated to dormancy. Here we identify the cell surface receptor neogenin-1 as specifically expressed in dormant HSCs. Loss of neogenin-1 initially leads to increased HSC expansion but subsequently to loss of self-renewal and premature exhaustion in vivo. Its ligand netrin-1 induces Egr1 expression and maintains quiescence and function of cultured HSCs in a Neo1 dependent manner. Produced by arteriolar endotheli ...[more]