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NiH-catalyzed asymmetric hydroarylation of N-acyl enamines to chiral benzylamines.

ABSTRACT: Enantiomerically pure chiral amines and related amide derivatives are privilege motifs in many pharmacologically active molecules. In comparison to the well-established hydroamination, the transition metal-catalysed asymmetric hydrofunctionalization of enamines provides a complementary approach for their construction. Here we report a NiH-catalysed enantio- and regioselective reductive hydroarylation of N-acyl enamines, allowing for the practical access to a broad range of structurally diverse, enantioenriched benzylamines under mild, operationally simple reaction conditions.

SUBMITTER: He Y

PROVIDER: S-EPMC7841163 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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NiH-catalyzed asymmetric hydroarylation of N-acyl enamines to chiral benzylamines.

He Yuli Y Song Huayue H Chen Jian J Zhu Shaolin S

Nature communications 20210127 1

Enantiomerically pure chiral amines and related amide derivatives are privilege motifs in many pharmacologically active molecules. In comparison to the well-established hydroamination, the transition metal-catalysed asymmetric hydrofunctionalization of enamines provides a complementary approach for their construction. Here we report a NiH-catalysed enantio- and regioselective reductive hydroarylation of N-acyl enamines, allowing for the practical access to a broad range of structurally diverse, ...[more]

PMID: 33504793

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