Cyclophosphamide arrhythmogenicitytesting using human-induced pluripotent stem cell-derived cardiomyocytes.
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ABSTRACT:
SUBMITTER: Podgurskaya AD
PROVIDER: S-EPMC7841168 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
Cyclophosphamide arrhythmogenicitytesting using human-induced pluripotent stem cell-derived cardiomyocytes.
Podgurskaya A D AD Slotvitsky M M MM Tsvelaya V A VA Frolova S R SR Romanova S G SG Balashov V A VA Agladze K I KI
Scientific reports 20210127 1
Cyclophosphamide (CP) is an anticancer drug, an alkylating agent. Cardiotoxicity of CP is associated with one of its metabolites, acrolein, and clinical cardiotoxicity manifestations are described for cases of taking CP in high doses. Nevertheless, modern arrhythmogenicity prediction assays in vitro include evaluation of beat rhythm and rate as well as suppression of cardiac late markers after acute exposure to CP, but not its metabolites. The mechanism of CP side effects when taken at low doses ...[more]
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