Ontology highlight
ABSTRACT: Importance
Prior research suggests an association between burden of disease and National Institutes of Health (NIH) funding. The allocation of NIH funding should reflect, to some extent, the health needs of the population, along with other factors.Objective
To examine the factors associated with NIH funding in 2019 for 46 diseases.Design, setting, and participants
This cohort study used disability-adjusted life-years to measure the 2008 and 2019 US burden of disease and compared them with NIH categoric funding for 46 diseases.Exposures
Disability-adjusted life-years to measure the 2008 and 2019 US burden of disease, 2016 health spending, and 2008 NIH funding levels for 46 diseases.Main outcomes and measures
2019 NIH funding levels for 46 diseases.Results
The 46 diseases accounted for 62?392?713 of 94?399?784 disability-adjusted life-years (66.1%) in 2008 and 75?706?718 of 111?074?472 disability-adjusted life-years (68.2%) in 2019, representing more than 66% of all disability-adjusted life-years in both years. By dollar volume, Alzheimer and dementia increased the most, with approximately $1.8 billion more funding in 2019 than 2008 (from $530 million in 2008 to $2398 million in 2019, a 352% increase), whereas interpersonal violence had the greatest decrease, $95 million, in 2019 NIH funding (from $236 million in 2008 to $141 million in 2019, a 40% decrease). For the 46 diseases in this study, the variable with the greatest association with NIH funding in 2019 was the level of NIH funding in 2008, with a simple correlation of 0.88. Burden of disease and changes in burden of disease were not statistically significantly associated with NIH funding levels once the prior level of funding was included in the model. The models suggested that a 1% higher level of NIH funding in 2008 was associated with a 0.91% higher level of NIH funding in 2019.Conclusions and relevance
In this study, NIH spending for most diseases seemed to be based primarily on the level of NIH spending more than 10 years earlier, despite changes in burden of disease. Congress and the NIH should examine the allocation process to ensure NIH investments are responsive to changes in the health of the population.
SUBMITTER: Ballreich JM
PROVIDER: S-EPMC7841468 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
JAMA network open 20210104 1
<h4>Importance</h4>Prior research suggests an association between burden of disease and National Institutes of Health (NIH) funding. The allocation of NIH funding should reflect, to some extent, the health needs of the population, along with other factors.<h4>Objective</h4>To examine the factors associated with NIH funding in 2019 for 46 diseases.<h4>Design, setting, and participants</h4>This cohort study used disability-adjusted life-years to measure the 2008 and 2019 US burden of disease and c ...[more]