Insulin resistance in transgender individuals correlates with android fat mass.
Ontology highlight
ABSTRACT: Background
Transgender individuals receiving gender-affirming hormone therapy (GAHT) are at increased risk of adverse cardiovascular outcomes. This may be related to effects on body composition and insulin resistance.Aims
To examine relationships between body fat distribution and insulin resistance in transgender individuals on established GAHT.Methods
Comparisons of body composition (dual energy X-ray absorptiometry) and insulin resistance [Homeostasis Model of Insulin Resistance (HOMA2-IR)] were made between transgender individuals (43 trans men and 41 trans women) on established GAHT (>12?months) and age-matched cisgender controls (30 males and 48 females). Multiple linear regressions were used to examine the relationship between HOMA2-IR and fat mass with gender, adjusting for age and total duration of GAHT and Pearson correlation coefficients are reported.Results
Compared with control cisgender women, trans men had mean difference of +7.8?kg (4.0, 11.5), p?p?p?p?=?0.001, lower android:gynoid fat ratio -0.1 (-0.2,-0.0), p?p?r 2?=?0.712, p?r 2?=?0.572, p?ConclusionAndroid fat more strongly correlates with insulin resistance than gynoid fat in transgender individuals. Higher fat mass and insulin resistance in trans women may predispose to increased cardiovascular risk. Despite adverse fat distribution, insulin resistance was not higher in trans men.
SUBMITTER: Bretherton I
PROVIDER: S-EPMC7841663 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Publications
Insulin resistance in transgender individuals correlates with android fat mass.
Bretherton Ingrid I Spanos Cassandra C Leemaqz Shalem Y SY Premaratne Gehan G Grossmann Mathis M Zajac Jeffrey D JD Cheung Ada S AS Cheung Ada S AS
Therapeutic advances in endocrinology and metabolism 20210123
<h4>Background</h4>Transgender individuals receiving gender-affirming hormone therapy (GAHT) are at increased risk of adverse cardiovascular outcomes. This may be related to effects on body composition and insulin resistance.<h4>Aims</h4>To examine relationships between body fat distribution and insulin resistance in transgender individuals on established GAHT.<h4>Methods</h4>Comparisons of body composition (dual energy X-ray absorptiometry) and insulin resistance [Homeostasis Model of Insulin R ...[more]
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