A novel BR-SMAD is required for larval development in barber's pole worm Haemonchus contortus.
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ABSTRACT:
SUBMITTER: Li F
PROVIDER: S-EPMC7841850 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
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A novel BR-SMAD is required for larval development in barber's pole worm <i>Haemonchus contortus</i>.
Li Fangfang F Qin Peixi P Ye Lisha L Gupta Nishith N Hu Min M
Microbial cell (Graz, Austria) 20201223 2
SMAD proteins mediate TGF-β signaling and thereby regulate the metazoan development; however, they are poorly defined in <i>Haemonchus contortus</i>-a common blood-sucking parasitic nematode of small ruminants. Here, we characterized an R-SMAD family protein in <i>H. contortus</i> termed <i>Hc</i>SMA2, which is closely related to <i>Caenorhabditis elegans</i> SMA2 (<i>Ce</i>SMA2) involved in the bone morphogenetic protein (BMP) signaling. <i>Hcsma2</i> is transcribed in all developmental stages ...[more]
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