Ontology highlight
ABSTRACT:
SUBMITTER: Elsallab M
PROVIDER: S-EPMC7841982 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
The Lancet. Oncology 20200201 2
Chimeric antigen receptor (CAR) T cells represent a potent new approach to treat haematological malignancies. Two CAR T-cell therapies, tisagenlecleucel and axicabtagene ciloleucel, have been approved in Europe and the USA, as well as several other countries, for the treatment of leukaemia and lymphoma. These approvals marked a major milestone in the field of cell and gene therapies. However, the clinical development and regulatory evaluation of these innovative therapies faced several challenge ...[more]