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Screen-detected atrial fibrillation predicts mortality in elderly subjects.


ABSTRACT:

Aims

Current guidelines recommend opportunistic screening for atrial fibrillation (AF) but the prognosis of individuals is unclear. The aim of this investigation is to determine prevalence and 1-year outcome of individuals with screen-detected AF.

Methods and results

We performed a prospective, pharmacy-based single time point AF screening study in 7107 elderly citizens (?65?years) using a hand-held, single-lead electrocardiogram (ECG) device. Prevalence of AF was assessed, and data on all-cause death and hospitalization for cardiovascular (CV) causes were collected over a median follow-up of 401 (372; 435) days. Mean age of participants was 74?±?5.9?years, with 58% (N?=?4130) of female sex. Automated heart rhythm analyses identified AF in 432 (6.1%) participants, with newly diagnosed AF in 3.6% of all subjects. During follow-up, 62 participants (0.9%) died and 390 (6.0%) were hospitalized for CV causes. Total mortality was 2.3% in participants with a screen-detected AF and 0.8% in subjects with a normal ECG [hazard ratio (HR) 2.94; 95% confidence interval (CI) 1.49-5.78; P?=?0.002]; hospitalization for CV causes occurred in 10.6% and 5.5%, respectively (HR 2.08; 95% CI 1.52-2.84; P?ConclusionPharmacy-based, automated AF screening in elderly citizens identified subjects with unknown AF and an excess mortality risk over the next year.

SUBMITTER: Zink MD 

PROVIDER: S-EPMC7842093 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Screen-detected atrial fibrillation predicts mortality in elderly subjects.

Zink Matthias D MD   Mischke Karl G KG   Keszei Andras P AP   Rummey Christian C   Freedman Ben B   Neumann Gabriele G   Tolksdorf Alina A   Frank Friederike F   Wienströer Jan J   Kuth Nicole N   Schulz Jörg B JB   Marx Nikolaus N  

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20210101 1


<h4>Aims</h4>Current guidelines recommend opportunistic screening for atrial fibrillation (AF) but the prognosis of individuals is unclear. The aim of this investigation is to determine prevalence and 1-year outcome of individuals with screen-detected AF.<h4>Methods and results</h4>We performed a prospective, pharmacy-based single time point AF screening study in 7107 elderly citizens (≥65 years) using a hand-held, single-lead electrocardiogram (ECG) device. Prevalence of AF was assessed, and da  ...[more]

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