Protective effect of glycyrrhizin on coronary microembolization-induced myocardial dysfunction in rats.
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ABSTRACT:
SUBMITTER: Yuan Y
PROVIDER: S-EPMC7842630 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
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Protective effect of glycyrrhizin on coronary microembolization-induced myocardial dysfunction in rats.
Yuan Yonggang Y Li Bing B Peng Wanzhong W Xu Zesheng Z
Pharmacology research & perspectives 20210201 1
Coronary microembolization (CME)-induced inflammation and cardiomyocyte apoptosis are two key factors contributing to CME-induced myocardial dysfunction. High-mobility group box-1 (HMGB1) plays essential role in progression of CME-induced injury and inhibition of HMGB1 has been shown to be protective. In present study, the potential effects of glycyrrhizin, a HMGB1 inhibitor, on CME-induced myocardial dysfunction are evaluated. Using a rat model of CME, we administrated glycyrrhizin in rats prio ...[more]
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