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Exosome-Derived Noncoding RNAs as a Promising Treatment of Bone Regeneration.

ABSTRACT: The reconstruction of large bone defects remains a crucial challenge in orthopedic surgery. The current treatments including autologous and allogenic bone grafting and bioactive materials have their respective drawbacks. While mesenchymal stem cell (MSC) therapy may address these limitations, growing researches have demonstrated that the effectiveness of MSC therapy depends on paracrine factors, particularly exosomes. This aroused great focus on the exosome-based cell-free therapy in the treatment of bone defects. Exosomes can transfer various cargoes, and noncoding RNAs are the most widely studied cargo through which exosomes exert their ability of osteoinduction. Here, we review the research status of the exosome-derived noncoding RNAs in bone regeneration, the potential application of exosomes, and the existing challenges.

SUBMITTER: Yin B

PROVIDER: S-EPMC7843188 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Exosome-Derived Noncoding RNAs as a Promising Treatment of Bone Regeneration.

Yin Bei B Ma Qingge Q Song Chenghao C Zhao Lingyi L Yu Fanyuan F Wang Chenglin C Shi Yu Y Ye Ling L

Stem cells international 20210121

The reconstruction of large bone defects remains a crucial challenge in orthopedic surgery. The current treatments including autologous and allogenic bone grafting and bioactive materials have their respective drawbacks. While mesenchymal stem cell (MSC) therapy may address these limitations, growing researches have demonstrated that the effectiveness of MSC therapy depends on paracrine factors, particularly exosomes. This aroused great focus on the exosome-based cell-free therapy in the treatme ...[more]

PMID: 33542737

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