Ontology highlight
ABSTRACT: Objective
To quantify rheumatoid arthritis (RA) cases attributable to selected non-genetic risk factors.Design
National Health and Nutrition Examination Survey (NHANES) and meta-analysis.Participants
US adults.Data sources
The prevalence of exposure was obtained from NHANES. Weighted analysis was performed to account for the complex sampling design in NHANES. PubMed and Web of Science up to 31 March 2019 were searched to identify epidemiological studies reported the association between non-genetic risk factors and RA in US adults. Relative risk (RR) value and the corresponding CI were pooled by meta-analysis to evaluate the associations between modifiable risk factors and RA. Population attributable fraction (PAF) was calculated based on the prevalence and RR data.Results
The weighted percentages of former smokers, current smokers and overweight or obese people were 24.84%, 23.93% and 63.97%, and the average alcohol consumption was 51.34 g/week. In the meta-analysis, we found that former smokers (RR 1.22, 95% CI 1.10 to 1.36) and current smokers (RR 1.47, 95% CI 1.29 to 1.68) had higher risks of RA. Overweight and obese individuals had 1.27-fold (95% CI 1.09 to 1.48) increased risk of RA. Each per 50 g/week increment of alcohol consumption was associated with 8% (95% CI 0% to 16%) reduction in the risk of RA. Therefore, PAF value of smoking was 14.00% (95% CI 8.13% to 23.33%). Excess body mass index (BMI) was found to account for 14.73% (95% CI 5.45% to 23.50%) of RA incidence. The fraction of RA risk attributed by low alcohol intake was 8.21% (95% CI 0.31% to 16.39%). Collectively, we found that 32.69% (95% CI 13.41% to 50.96%) of RA cases were attributable to smoking, overweight or obesity and low alcohol drinking.Conclusion
Nearly 33% of RA incidence was attributed to smoking, excess BMI and low alcohol drinking in USA. Our findings could provide a basis for developing guidelines of RA prevention and control in USA.
SUBMITTER: Ye D
PROVIDER: S-EPMC7843328 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Ye Ding D Mao Yingying Y Xu Yang Y Xu Xueli X Xie Zhijun Z Wen Chengping C
BMJ open 20210126 1
<h4>Objective</h4>To quantify rheumatoid arthritis (RA) cases attributable to selected non-genetic risk factors.<h4>Design</h4>National Health and Nutrition Examination Survey (NHANES) and meta-analysis.<h4>Participants</h4>US adults.<h4>Data sources</h4>The prevalence of exposure was obtained from NHANES. Weighted analysis was performed to account for the complex sampling design in NHANES. PubMed and Web of Science up to 31 March 2019 were searched to identify epidemiological studies reported t ...[more]