Ontology highlight
ABSTRACT:
SUBMITTER: Tsiouplis NJ
PROVIDER: S-EPMC7843795 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Tsiouplis Nikolas James NJ Bailey David Wesley DW Chiou Lilly Felicia LF Wissink Fiona Jane FJ Tsagaratou Ageliki A
Frontiers in cell and developmental biology 20210115
TET proteins oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and further oxidation products in DNA. The oxidized methylcytosines (oxi-mCs) facilitate DNA demethylation and are also novel epigenetic marks. TET loss-of-function is strongly associated with cancer; <i>TET2</i> loss-of-function mutations are frequently observed in hematological malignancies that are resistant to conventional therapies. Importantly, TET proteins govern cell fate decisions during development of various ...[more]