Ontology highlight
ABSTRACT:
SUBMITTER: Qiu X
PROVIDER: S-EPMC7844284 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Qiu Xuemei X Jiang Sheng S Xiao Yanxuan Y He Yumin Y Ren Tao T Jiang Lu L Liu Rui R Chen Qianming Q
International journal of oral science 20210129 1
Oral squamous cell carcinoma (OSCC) become a heavy burden of public health, with approximately 300 000 newly diagnosed cases and 145 000 deaths worldwide per year. Nucleotide metabolism fuel DNA replication and RNA synthesis, which is indispensable for cell proliferation. But how tumor cells orchestrate nucleotide metabolic enzymes to support their rapid growth is largely unknown. Here we show that expression of pyrimidine metabolic enzyme dihydroorotate dehydrogenase (DHODH) is upregulated in O ...[more]