Ontology highlight
ABSTRACT:
SUBMITTER: Zelante T
PROVIDER: S-EPMC7844877 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Cell reports 20210101 4
Indoleamine 2,3-dioxygenases (IDOs) degrade l-tryptophan to kynurenines and drive the de novo synthesis of nicotinamide adenine dinucleotide. Unsurprisingly, various invertebrates, vertebrates, and even fungi produce IDO. In mammals, IDO1 also serves as a homeostatic regulator, modulating immune response to infection via local tryptophan deprivation, active catabolite production, and non-enzymatic cell signaling. Whether fungal Idos have pleiotropic functions that impact on host-fungal physiolog ...[more]