Ontology highlight
ABSTRACT:
SUBMITTER: Li D
PROVIDER: S-EPMC7845732 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Li Danyang D Yang Yang Y Chen Bo B Guo Xinghong X Gao Shuang S Wang Meng M Duan Mingxiao M Li Xiangzhi X
Frontiers in pharmacology 20201208
MOF is a well-known histone acetyltransferase to catalyze acetylation of histone H4 lysine 16 (K16), and it is relevant to diverse biological processes, such as gene transcription, cell cycle, early embryonic development and tumorigenesis. Here, we identify MOF as an oncogene in most thyroid cancer. It is found that expression level of MOF was significantly upregulated in most thyroid cancer tissue samples and cell lines. MOF-deficient in both BHP-10-3 and TT2609 cell lines inhibited cell prolif ...[more]