Dataset Information

Effects of visual impairment on mobility functions in elderly: Results of Fujiwara-kyo Eye Study.

ABSTRACT: The aim of this study was to determine whether there is a significant association between a visual impairment (VI) and mobility functions in an elderly Japanese cohort. The subjects of this study were part of the Fujiwara-kyo Eye Study, a cross sectional epidemiological study of elderly individuals conducted by Nara Medical University. Participants were ?70-years who lived in the Nara Prefecture. All underwent comprehensive ophthalmological examinations, and a VI was defined as a best-corrected visual acuity (BCVA) worse than 20/40 in the better eye. The associations between the BCVA and walking speed and one-leg standing time were determined. The medical history and health conditions were evaluated by a self-administered questionnaire. A total of the 2,809 subjects whose mean age was 76.3 ± 4.8 years (± standard deviation) were studied. The individuals with a VI (2.1%) had significantly slower walking speeds and shorter one-leg standing times than that of the non-VI individuals (1.5±0.4 vs 1.7±0.4 m/sec, P<0.01; 17.1±19.6 vs 27.6±21.3 sec, P<0.01, respectively). Univariate logistic regression found that the odds ratio (OR) for the slower walking speed (<1 m/sec) in the VI individuals was significantly higher at 7.40 (3.36-16.30;95% CI, P <0.001) than in non-VI individuals. It was still significantly higher at 4.50 (1.87-10.85;95% CI, P = 0.001) in the multivariate logistic regression model after adjusting for the BCVA, age, sex, current smoking habit, and health conditions. Our results indicate that the walking speed and one-leg standing times were significantly associated with VI.

SUBMITTER: Miyata K

PROVIDER: S-EPMC7845963 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Effects of visual impairment on mobility functions in elderly: Results of Fujiwara-kyo Eye Study.

Miyata Kimie K Yoshikawa Tadanobu T Harano Akihiro A Ueda Tetsuo T Ogata Nahoko N

PloS one 20210129 1

The aim of this study was to determine whether there is a significant association between a visual impairment (VI) and mobility functions in an elderly Japanese cohort. The subjects of this study were part of the Fujiwara-kyo Eye Study, a cross sectional epidemiological study of elderly individuals conducted by Nara Medical University. Participants were ≥70-years who lived in the Nara Prefecture. All underwent comprehensive ophthalmological examinations, and a VI was defined as a best-corrected ...[more]

PMID: 33513151

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Project description:ImportanceWorsening vision and declining cognitive functioning are common conditions among elderly individuals. Understanding the association between them could be beneficial in mitigating age-related cognitive changes.ObjectiveTo evaluate the longitudinal associations between visual impairment and cognitive function over time in a population-based study of older US adults.Design, setting, and participantsProspective longitudinal population-based study of older adults in the greater Salisbury area in Maryland. Overall, 2520 community-residing adults aged 65 to 84 years were assessed at baseline between September 1993 and August 1995 (round 1) and 2 (round 2), 6 (round 3), and 8 (round 4) years later.Main outcomes and measuresVisual acuity (VA) was measured using Early Treatment Diabetic Retinopathy Study charts, and cognitive status was assessed using the Mini-Mental State Examination (MMSE).ResultsOf 2520 individuals, the mean (SD) age was 73.5 (5.1) years, 1458 (58%) were women, and 666 (26%) were black. There were 2240 (89%), 1504 (61%), and 1250 (50%) participants in the second, third, and fourth round of study, respectively, with more than half of the loss being due to death. Both VA and MMSE score worsened over time. The mean biannual decline of VA was 0.022 logMAR (approximately 1 line during 8 years; 95% CI, 0.018-0.026), and the mean biannual worsening of MMSE score was -0.59 (95% CI, -0.64 to -0.54; both P < .001). Worse baseline VA was associated with worse baseline MMSE score (r = -0.226; 95% CI, -0.291 to -0.16; P < .001). The rate of worsening VA was associated with the rate of declining MMSE score (r = -0.139; 95% CI, -0.261 to -0.017; P = .03). Cross-lagged models indicated VA in the previous round was associated with MMSE score in the subsequent round (β = -0.995, P < .001), and MMSE score in the previous round was associated with VA in the following round (β = -0.003, P < .001). However, the standardized effect size of VA on MMSE score (β = -0.074; SE, 0.015; P < .001) is larger relative to the reverse effect (β = -0.038; SE, 0.013; P < .001), demonstrating VA is likely the driving force in these dynamic associations.Conclusions and relevanceIn a population-based sample of older US adults, visual impairment measured at distance is associated with declining cognitive function both cross-sectionally and longitudinally over time with worsening vision having a stronger association with declining cognition than the reverse. Worsening vision in older adults may be adversely associated with future cognitive functioning. Maintaining good vision may be an important interventional strategy for mitigating age-related cognitive declines.

Dataset Information

Effects of visual impairment on mobility functions in elderly: Results of Fujiwara-kyo Eye Study.

Publications

Effects of visual impairment on mobility functions in elderly: Results of Fujiwara-kyo Eye Study.

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