Ontology highlight
ABSTRACT:
SUBMITTER: Lindblad JL
PROVIDER: S-EPMC7846589 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Lindblad Jillian L JL Tare Meghana M Amcheslavsky Alla A Shields Alicia A Bergmann Andreas A
Scientific reports 20210129 1
The initiator caspase Dronc is the only CARD-domain containing caspase in Drosophila and is essential for apoptosis. Here, we report that homozygous dronc mutant adult animals are short-lived due to the presence of a poorly developed, defective and leaky intestine. Interestingly, this mutant phenotype can be significantly rescued by enteroblast-specific expression of dronc<sup>+</sup> in dronc mutant animals, suggesting that proper Dronc function specifically in enteroblasts, one of four cell ty ...[more]