Ontology highlight
ABSTRACT:
SUBMITTER: Chin WX
PROVIDER: S-EPMC7846741 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
NPJ vaccines 20210129 1
The mosquito-borne Zika virus is an emerging pathogen from the Flavivirus genus for which there are no approved antivirals or vaccines. Using the clinically validated PDK-53 dengue virus vaccine strain as a backbone, we created a chimeric dengue/Zika virus, VacDZ, as a live attenuated vaccine candidate against Zika virus. VacDZ demonstrates key markers of attenuation: small plaque phenotype, temperature sensitivity, attenuation of neurovirulence in suckling mice, and attenuation of pathogenicity ...[more]