Ontology highlight
ABSTRACT:
SUBMITTER: Wagstaffe HR
PROVIDER: S-EPMC7846750 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Wagstaffe Helen R HR Susannini Giada G Thiébaut Rodolphe R Richert Laura L Lévy Yves Y Bockstal Viki V Stoop Jeroen N JN Luhn Kerstin K Douoguih Macaya M Riley Eleanor M EM Lacabaratz Christine C Goodier Martin R MR
NPJ vaccines 20210129 1
Natural killer (NK) cells are implicated among immune effectors after vaccination against viral pathogens, including Ebola virus. The two-dose heterologous Ebola virus vaccine regimen, adenovirus type 26.ZEBOV followed by modified vaccinia Ankara-BN-Filo (EBOVAC2 consortium, EU Innovative Medicines Initiative), induces NK cell activation and anti-Ebola glycoprotein (GP) antibody-dependent NK cell activation post-dose 1, which is further elevated post-dose 2. Here, in a multicentre, phase 2 clini ...[more]