Dataset Information

Baseline monocyte and its classical subtype may predict efficacy of PD-1/PD-L1 inhibitor in cancers.

ABSTRACT:

Background

Programmed death 1 (PD-1)/ programmed?death-ligand?1 (PD-L1) inhibitor is one of the most popular immune therapies. Biomarkers for predicting response are highly needed, but no biomarkers are widely used till now.

Patients and methods

From February 2018 to April 2019, pan-cancer patients treated with PD-1 or PD-L1 inhibitor as a single agent in our center were included. The benefit group included patients with partial response, complete response and stable disease, while the patients with progressive disease were classified into the non-benefit group, according to the RECIST 1.1 criteria. Baseline peripheral blood was sampled to determine absolute monocyte count (AMC) and/or classical monocyte frequency (CMF) of peripheral blood mononuclear cells. Then, the association of the above-mentioned two biomarkers with response or progression-free survival (PFS) was evaluated.

Results

In total, 107 patients enrolled in this study. The non-benefit group had significantly larger number of AMC than benefit group (P <0.001), and patients with higher AMC had decreased PFS time (P =0.001). Of 39 patients tested for CMF, the non-benefit group had significantly higher CMF than benefit group (P =0.002), and patients with higher CMF had significantly decreased PFS time (P =0.002). The sensitivity of AMC and CMF was 87.9% and 85.7% respectively, and the specificity was 44.9% and 61.1% respectively. Multivariate analysis showed high baseline CMF and AMC were both significantly associated with decreased PFS time.

Conclusion

Baseline CMF and baseline AMC can be potential pan-cancer biomarkers to predict efficacy of PD-1/PD-L1 inhibitors, especially in the PD-L1 subgroup.

SUBMITTER: Shao Y

PROVIDER: S-EPMC7846968 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Publications

Baseline monocyte and its classical subtype may predict efficacy of PD-1/PD-L1 inhibitor in cancers.

Shao Yilin Y Lin Shuchen S Zhang Ping P Zhang Jian J Ji Dongmei D Tao Zhonghua Z Hu Xichun X

Bioscience reports 20210101 1

<h4>Background</h4>Programmed death 1 (PD-1)/ programmed death-ligand 1 (PD-L1) inhibitor is one of the most popular immune therapies. Biomarkers for predicting response are highly needed, but no biomarkers are widely used till now.<h4>Patients and methods</h4>From February 2018 to April 2019, pan-cancer patients treated with PD-1 or PD-L1 inhibitor as a single agent in our center were included. The benefit group included patients with partial response, complete response and stable disease, whil ...[more]

PMID: 33440424

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Dataset Information

Baseline monocyte and its classical subtype may predict efficacy of PD-1/PD-L1 inhibitor in cancers.

Background

Patients and methods

Results

Conclusion

Publications

Baseline monocyte and its classical subtype may predict efficacy of PD-1/PD-L1 inhibitor in cancers.

Similar Datasets

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