Ontology highlight
ABSTRACT:
SUBMITTER: Redl S
PROVIDER: S-EPMC7847270 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Development (Cambridge, England) 20210120 2
Primordial germ cells (PGCs) are the precursors of germ cells, which migrate to the genital ridge during early development. Relatively little is known about PGCs after their migration. We studied this post-migratory stage using microscopy and sequencing techniques, and found that many PGC-specific genes, including genes known to induce PGC fate in the mouse, are only activated several days after migration. At this same time point, PGC nuclei become extremely gyrated, displaying general broad ope ...[more]