Risk for Nephrogenic Systemic Fibrosis After Exposure to Newer Gadolinium Agents: A Systematic Review.

ABSTRACT:

Background

The risk for nephrogenic systemic fibrosis (NSF) after exposure to newer versus older gadolinium-based contrast agents (GBCAs) remains unclear.

Purpose

To synthesize evidence about NSF risk with newer versus older GBCAs across the spectrum of kidney function.

Data sources

MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and Web of Science for English-language references from inception to 5 March 2020.

Study selection

Randomized controlled trials, cohort studies, and case-control studies that assessed NSF occurrence after GBCA exposure.

Data extraction

Data were abstracted by 1 investigator and verified by a second. Investigator pairs assessed risk of bias by using validated tools.

Data synthesis

Of 32 included studies, 2

SUBMITTER: Lunyera J 

PROVIDER: S-EPMC7847719 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature